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Volume 356:868-869 February 22, 2007 Number 8
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Chloroquine-Resistant Malaria in Malawi

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by Laufer, M. K.
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To the Editor: In their article on the efficacy of chloroquine against Plasmodium falciparum in Blantyre, Malawi, Laufer and colleagues (Nov. 9 issue)1 report adequate clinical and parasitologic responses to chloroquine and the microevolutionary replacement of the T76 marker for the P. falciparum chloroquine-resistance transporter gene (PfCRT)2 by the sensitive wild-type marker for choroquine susceptibility (K76) — the prevalence of which increased in local parasite populations after use of the drug had been suspended for several years3 — as a result of restored fitness of the wild-type strains. If the authors' recommendation to largely withdraw chloroquine from use . . . [Full Text of this Article]



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