Preimplantation genetic diagnosis, first described in 1990,1involves removing one or two cells from an embryo for genetictesting in order to prevent transmission of genetic disordersfrom a parent who is known to carry a genetic abnormality. Genetictests are done on the third day after in vitro fertilization(IVF), when the embryos are at the eight-cell stage of development;only embryos without specific genetic traits are transferredto the mother a day or two later. The procedures involved arepolymerase chain reaction (PCR) for known single-gene defectsor fluorescence in situ hybridization (FISH) to identify chromosomalabnormalities. Of . . . [Full Text of this Article]
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From the Faculty of Health Sciences, McMaster University, Hamilton, ON; and the Faculty of Medicine, Dalhousie University, Halifax, NS — both in Canada.
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