In this issue of the Journal,1 Home and colleagues report interimresults from the Rosiglitazone Evaluated for Cardiac Outcomesand Regulation of Glycaemia in Diabetes, or RECORD, study (NCT00379769
[ClinicalTrials.gov]
).The RECORD study is a 6-year, open-label, noninferiority trialin which patients with type 2 diabetes who had inadequate glucosecontrol with metformin or sulfonylurea alone were randomly assignedto receive rosiglitazone (Avandia) or the combination of metforminand sulfonylurea. The primary outcome was a composite of hospitalizationand death from cardiovascular causes. As of March 2007, datawere available on the 4447 patients randomly assigned to receiveone of . . . [Full Text of this Article]
Source Information
From the Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, and the Center for Health Studies, Group Health, Seattle (B.M.P.); and the Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC (C.D.F.).
This article (10.1056/NEJMe078116) was published at www.nejm.org on June 5, 2007.
This article has been cited by other articles:
Biserni, A., Giannessi, F., Sciarroni, A. F., Milazzo, F. M., Maggi, A., Ciana, P.
(2008). In Vivo Imaging Reveals Selective Peroxisome Proliferator Activated Receptor Modulator Activity of the Synthetic Ligand 3-(1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886). Mol. Pharmacol.
73: 1434-1443
[Abstract][Full Text]
(2008). Glitazones in type 2 diabetes: an update. DTB
46: 25-29
[Abstract][Full Text]
Hoffman, J. M., Shah, N. D., Vermeulen, L. C., Doloresco, F., Grim, P., Hunkler, R. J., Hontz, K. M., Schumock, G. T.
(2008). Projecting future drug expenditures--2008. Am J Health Syst Pharm
65: 234-253
[Abstract][Full Text]
Nathan, D. M., Buse, J. B., Davidson, M. B., Ferrannini, E., Holman, R. R., Sherwin, R., Zinman, B.
(2008). Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: Update regarding thiazolidinediones: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes . Diabetes Care
31: 173-175
[Full Text]
Diamond, G. A., Bax, L., Kaul, S.
(2007). Uncertain Effects of Rosiglitazone on the Risk for Myocardial Infarction and Cardiovascular Death. ANN INTERN MED
147: 578-581
[Abstract][Full Text]