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Previous Volume 357:1037-1039 September 6, 2007 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The overall goals of clinical research in the intensive care unit (ICU) are to improve clinical outcomes through enhanced understanding of how critical illness develops and how such illness is best prevented, diagnosed, treated, or palliated. Several "normal" physiological measurements and laboratory values have been abandoned as therapeutic targets during critical illness, since in some randomized trials, attempts to normalize these measurements and values have shown either harm or no benefit with respect to clinical outcomes.

One such target is the hemoglobin concentration. Anemia is commonly acquired in the ICU owing to hemodilution, blood loss, reduced red-cell production, and enhanced . . . [Full Text of this Article]

Source Information

From the Departments of Medicine (D.C., M.C.) and Clinical Epidemiology and Biostatistics (D.C.), St. Joseph's Healthcare, McMaster University, Hamilton, ON, Canada.

This article has been cited by other articles:

• Zarychanski, R. MD, Turgeon, A. F. MD MSc, McIntyre, L. MD MHSc, Fergusson, D. A. MHA PhD (2007). Erythropoietin-receptor agonists in critically ill patients: a meta-analysis of randomized controlled trials. CMAJ 177: 725-734 [Abstract] [Full Text]  
• (2007). Erythropoietin in the ICU Mixed Results. JWatch General 2007: 1-1 [Full Text]