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Previous Volume 357:1121-1135 September 13, 2007 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Coronary heart disease is the leading cause of death worldwide, and 3.8 million men and 3.4 million women die of the disease each year. After an acute myocardial infarction, early and successful myocardial reperfusion with the use of thrombolytic therapy or primary percutaneous coronary intervention (PCI) is the most effective strategy for reducing the size of a myocardial infarct and improving the clinical outcome. The process of restoring blood flow to the ischemic myocardium, however, can induce injury. This phenomenon, termed myocardial reperfusion injury, can paradoxically reduce the beneficial effects of myocardial reperfusion.

The potentially detrimental aspect of myocardial reperfusion . . . [Full Text of this Article]

Myocardial Reperfusion Injury and Cell Death

Potential Mediators of Lethal Reperfusion Injury

Oxygen Paradox

Calcium Paradox

pH Paradox

Inflammation

Metabolic Modulation

Magnesium Therapy

Therapeutic Hypothermia

Mitochondrial PTP

Targeting Lethal Reperfusion Injury

New Strategies for Preventing Lethal Reperfusion Injury

Ischemic Postconditioning

Targeting the RISK Pathway

Targeting the Mitochondrial PTP

Wavefront of Reperfusion Injury

Conclusions

Source Information

From the Hatter Cardiovascular Institute, University College London Hospital and Medical School, London.

Address reprint requests to Dr. Yellon at the Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London WC1E 6HX, United Kingdom, or at hatter-institute@ucl.ac.uk.

Related Letters:

Myocardial Reperfusion Injury
Ramaraj R., Forman M. B., Jackson E. K., Lowenstein C. J., Ibanez B., Cimmino G., Badimon J. J., Korantzopoulos P. G., Goudevenos J. A., Yellon D. M., Hausenloy D. J.
Extract | Full Text | PDF  
N Engl J Med 2007; 357:2408-2410, Dec 6, 2007. Correspondence

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