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Correspondence
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Volume 357:1154-1156 September 13, 2007 Number 11
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Human Papillomavirus Vaccine

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To the Editor: In their editorial about the availability of a quadrivalent vaccine against human papillomavirus (HPV) (Gardasil, Merck) that was reported on by Garland et al.1 and by the Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) II Study Group2 (May 10 issue), Sawaya and Smith-McCune3 raise concerns regarding the adequacy of cervical dysplasia as an efficacy end point, disease due to HPV types not associated with the vaccine, the lower efficacy of the vaccine among women who were previously infected with HPV than among those who had never been infected, and the need for continued Papanicolaou screening after . . . [Full Text of this Article]




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