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Previous Volume 357:1156-1158 September 13, 2007 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The study by D'Souza et al. (May 10 issue)¹ on oropharyngeal squamous-cell carcinomas associated with human papillomavirus (HPV) provides important epidemiologic insights into a cancer that is becoming increasingly common in the United States.² However, the molecular mechanisms of carcinogenesis in HPV-associated oropharyngeal squamous-cell carcinomas remain unclear.

The integration of HPV type 16 (HPV-16) into the host genome is an important mechanism in cervical carcinogenesis,³ but there is no direct evidence that this process occurs in oropharyngeal squamous-cell carcinomas. The authors state that Southern blot, real-time polymerase-chain-reaction (PCR), and fluorescence in situ hybridization analyses⁴ have established integration . . . [Full Text of this Article]

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