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Volume 357:1262-1263 September 20, 2007 Number 12
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Erythropoietins in Oncology

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 by Khuri, F. R.
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To the Editor: Khuri (June 14 issue)1 highlights safety concerns regarding the use of erythropoiesis-stimulating agents (ESAs) in patients with cancer. The studies that have given rise to these concerns used significantly higher hemoglobin targets than those used in the community or recommended in widely used guidelines,2,3 and thus do not reflect the current standard of care. The only study that did not use an excessively high hemoglobin target has not been published and cannot be accurately reviewed.

In these studies, treatment with ESAs was initiated in patients with hemoglobin levels as high as 14.5 g per deciliter. Many of . . . [Full Text of this Article]




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