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Previous Volume 357:1316-1325 September 27, 2007 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Medical progress has altered the course and thus the definition of uremia, which once encompassed all the signs and symptoms of advanced kidney failure. Hypertension due to volume overload, hypocalcemic tetany, and anemia due to erythropoietin deficiency were once considered signs of uremia but were removed from this category as their causes were discovered. Today the term "uremia" is used loosely to describe the illness accompanying kidney failure that cannot be explained by derangements in extracellular volume, inorganic ion concentrations, or lack of known renal synthetic products. We now assume that uremic illness is due largely to the accumulation of . . . [Full Text of this Article]

Solutes Cleared by the Kidney and Retained in Uremia

Solute Removal by Dialysis

Large Solutes

Solutes Bound to Albumin

Sequestered Solutes

Signs and Symptoms of Uremia

Metabolic Effects of Uremia

Cellular Functions

Why is the Glomerular Filtration Rate Normally So High?

Future Studies

Summary

Source Information

From Stanford University School of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA (T.W.M.), and the Albert Einstein College of Medicine, New York (T.H.H.).

Address reprint requests to Dr. Hostetter at the Albert Einstein College of Medicine, Rm. 615, Ullmann Bldg., 1300 Morris Park Ave., Bronx, NY 10461, or at thostett@aecom.yu.edu.

Related Letters:

Uremia
Haddy F. J., Meyer T. W., Hostetter T. H.
Extract | Full Text | PDF  
N Engl J Med 2008; 358:95, Jan 3, 2008. Correspondence

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