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Case Records of the Massachusetts General Hospital
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Volume 357:1327-1335 September 27, 2007 Number 13
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Case 30-2007 — A Newborn Girl with Skin Lesions
Mathew M. Avram, M.D., J.D., Verena Gobel, M.D., and Alireza Sepehr, M.D.

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Presentation of Case

Dr. Elizabeth A. Buzney (Dermatology): A newborn girl was transferred to this hospital because of a rash that had been present at birth. The infant, who weighed 3105 g, was born by spontaneous vaginal delivery at 40 weeks' gestation to a healthy 27-year-old mother after an uncomplicated pregnancy. At birth, no meconium was present, and the Apgar score was 7 at 1 minute and 9 at 5 minutes. On examination, numerous skin lesions, described as pustules and scabs, were present on the face, trunk, arms, and legs. A Tzanck smear was reported to be positive for multinucleated giant cells. Lumbar . . . [Full Text of this Article]

Differential Diagnosis

Infectious Neonatal Vesiculopustular Dermatoses

            HSV

            Varicella

            Cytomegalovirus

            Candida

            Bacterial Infection

            Congenital Syphilis

Noninfectious Conditions in the Neonate with Vesicles and Erosions

Nontransient Bullous Dermatoses of the Neonate

Langerhans'-Cell Histiocytosis

Dr. Mathew M. Avram's Diagnosis

Pathological Discussion

Discussion of Management

Anatomical Diagnosis


Source Information

From the Departments of Dermatology (M.M.A.), Pediatrics (V.G.), and Pathology (A.S.), Massachusetts General Hospital and Harvard Medical School.



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