A cell's ability to give to rise to all the cell types of theembryo and the adult organism is called pluripotency. Pluripotentcells are found within mammalian blastocysts and persist brieflyin embryos after implantation. Embryonic stem cells, derivedfrom the inner cell mass of blastocysts, are a renewable sourceof pluripotent stem cells that are proving valuable in basicscience studies and may eventually become a source of cellsfor safe, effective cell-based therapies. Much embryonic stem-cellresearch has focused on determining the molecular signatureof pluripotency, and a picture is emerging of a complex interactionamong transcription . . . [Full Text of this Article]
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Dr. Gearhart is a professor of gynecology and obstetrics, physiology, comparative medicine, and biochemistry and molecular biology and the director of the Stem Cell Biology Program at the Institute for Cell Engineering, Johns Hopkins Medical Institutions, Baltimore, where Ms. Pashos and Ms. Prasad are Ph.D. candidates in the Human Genetics and Molecular Biology Program.
An interview with Dr. Douglas Melton, a scientific director of the Harvard Stem Cell Institute and a professor in the Department of Molecular and Cellular Biology at Harvard University, can be heard at www.nejm.org.
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