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Previous Volume 357:1472-1475 October 11, 2007 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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September 12, 2007, marked the 50th anniversary of E. Donnall (Don) Thomas's initial report of a radical new approach to cancer treatment: radiation and chemotherapy followed by the intravenous infusion of bone marrow.¹ That publication represented the beginning of a long series of laboratory and clinical investigations; more than a decade would pass before the procedure achieved its first successes. Yet Thomas's persistence in the face of criticism and clinical failure ultimately paid off in a new form of therapy that was used to treat approximately 50,000 people worldwide in 2006 (see timeline).

View larger version (31K):   Timeline Showing Numbers of Bone Marrow . . . [Full Text of this Article]

 

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Dr. Appelbaum is director of the Clinical Research Division of the Fred Hutchinson Cancer Research Center and head of the Division of Medical Oncology at the University of Washington — both in Seattle.

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