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Volume 357:1667-1668 October 18, 2007 Number 16
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STAT3 Mutation in the Original Patient with Job's Syndrome

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by Holland, S. M.
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To the Editor: In 1966, a report on two unrelated young girls who had had recurrent staphylococcal abscesses since infancy was introduced with the biblical quote, "So went Satan forth from the presence of the Lord, and smote Job with sore boils from the sole of his foot unto his crown" (Job 2:7).1 The authors called this disorder the Job syndrome because of the phenotypic similarity to the biblical figure Job. Subsequently, similar patients were recognized and noted to have markedly elevated IgE levels, leading to the name "hyper-IgE syndrome" (HIES). (Details about the second girl, who died at the . . . [Full Text of this Article]



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