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Previous Volume 357:1769-1771 October 25, 2007 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Mastenbroek et al. (July 5 issue)¹ report a detrimental effect of preimplantation genetic screening, performed in women of advanced maternal age, on rates of ongoing pregnancy and live birth. We believe this outcome is explained by problems with the authors' methods, both for biopsy and for diagnosis.

As Mastenbroek and colleagues note, pregnancy rates after in vitro fertilization (IVF) steadily decline with increasing maternal age, while rates of pregnancy loss concurrently increase. These observations are attributed mostly to chromosome abnormalities in embryos obtained after follicular stimulation (which range from 50% among young patients to nearly 80% among . . . [Full Text of this Article]

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