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Volume 357:1979-1980 November 8, 2007 Number 19
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Prevention of Preterm Delivery

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by Simhan, H. N.
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To the Editor: The review article on prevention of preterm delivery, by Simhan and Caritis (Aug. 2 issue),1 may suggest that oxytocin-receptor antagonists should not be used for the treatment of preterm labor because of a possible excess of fetal and infant deaths. We believe that the authors rely on studies that are methodologically questionable, based on the literature. The elevated infant mortality in the studies cited is probably related to randomization bias, in our view.2,3 More recent randomized trials4,5 show similar tocolytic efficacy, fewer maternal side effects, and no excess infant deaths with atosiban, as compared with other tocolytic . . . [Full Text of this Article]



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