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A 45-year-old male farmer presented with a 2-month history of increasing breathlessness and dry cough. His arterial oxygen saturation was 82% while he was breathing ambient air, and his chest radiograph showed bilateral alveolar and interstitial opacities. High-resolution computed tomography (CT) of the chest showed a bilateral ground-glass opacity with interlobular septal thickening, creating a mosaic, or "crazy paving," pattern in both lung fields. Pulmonary-function testing showed a moderately restrictive ventilatory defect, with a forced vital capacity of 54% and a diffusion capacity of 37% of the predicted values. Transbronchial lung biopsy showed alveolar filling with amorphous, granular, eosinophilic, periodic . . . [Full Text of this Article] |
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