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Previous Volume 357:154-162 July 12, 2007 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text  Full Text Audio PowerPoint Slide Set CME Exam Supplementary Material Purchase this article Editorial by Hartge, P. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations.

A healthy 33-year-old woman comes to establish care. She reports no breast symptoms, her age at menarche was 14, and she has no children. She notes a family history of early-onset breast cancer in her sister (whose condition was diagnosed at the age of 35 years and who is alive at 39 years), mother (diagnosed at 37 years and alive at 60 . . . [Full Text of this Article]

The Clinical Problem

Strategies and Evidence

Risk Assessment and Genetic Testing

Specialized Breast-Cancer Surveillance

            Breast Examination

            Mammography

            Magnetic Resonance Imaging

            Ultrasonography

Screening for Other Cancers

Strategies for Reducing Risks

            Chemoprevention

            Surgery

Areas of Uncertainty

Recommendations from Professional Societies

Summary and Conclusions

Source Information

From the Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York.

Address reprint requests to Dr. Robson at the Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021, or at robsonm@mskcc.org.

Related Letters:

Management of an Inherited Predisposition to Breast Cancer
Sardanelli F., Podo F., Robson M., Offit K.
Extract | Full Text | PDF  
N Engl J Med 2007; 357:1663, Oct 18, 2007. Correspondence

This article has been cited by other articles:

• Rebora, P., Czene, K., Reilly, M. (2008). Timing of Familial Breast Cancer in Sisters. JNCI J Natl Cancer Inst 0: djn146v1-727 [Abstract] [Full Text]  
• (2008). BRCA Screening. Obstet Gynecol 111: 1205-1206 [Full Text]  
• Briasoulis, E., Roukos, D. H. (2008). Contralateral Prophylactic Mastectomy: Mind the Genetics. JCO 26: 1909-1910 [Full Text]  
• Offit, K. (2008). Genomic Profiles for Disease Risk: Predictive or Premature?. JAMA 299: 1353-1355 [Full Text]  
• Sardanelli, F., Podo, F., Robson, M., Offit, K. (2007). Management of an Inherited Predisposition to Breast Cancer. NEJM 357: 1663-1663 [Full Text]