Learning whether a patient who has just been given a diagnosisof breast cancer also bears one of the cancer-causing mutationsin the BRCA1 or BRCA2 genes may add little to the clinician'sability to select a therapy or predict the course of disease,once the grade and receptor status of the tumor and the ageof the patient are taken into account. In this issue of theJournal, Rennert et al.1 support that line of reasoning withtheir study of Israeli women in whom breast cancer was diagnosedin 1987 or 1988. Reliable data on clinical outcomes in carriers. . . [Full Text of this Article]
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From the Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD.
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