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Previous Volume 357:2426-2429 December 13, 2007 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In Stockholm this fall, the Nobel Prize in Medicine or Physiology was awarded to Martin Evans, Oliver Smithies, and Mario Capecchi for their discoveries of "principles for introducing specific gene modifications in mice by the use of embryonic stem cells." The methods they developed make possible exquisitely detailed studies of the function of almost any gene in a living animal. Given the high degree of similarity between the mouse and human genomes, this technology of gene manipulation has important clinical implications.

The concept of genetically engineering a mouse is straightforward: devise a specific genetic modification in a chromosome of embryonic . . . [Full Text of this Article]

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Dr. Manis is an assistant professor in the Department of Pathology, Harvard Medical School, and an investigator in the Department of Laboratory Medicine and the Joint Program in Transfusion Medicine at Children's Hospital — both in Boston.

An interview with Dr. Susan Dymecki, associate professor of genetics at Harvard Medical School, can be heard at www.nejm.org.

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