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Previous Volume 357:2482-2494 December 13, 2007 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Platelets are essential for primary hemostasis and repair of the endothelium, but they also play a key role in the development of acute coronary syndromes and contribute to cerebrovascular events. In addition, they participate in the process of forming and extending atherosclerotic plaques. Atherosclerosis is a chronic inflammatory process,¹ and inflammation is an important component of acute coronary syndromes.² The relation between chronic and acute vascular inflammation is unclear, but platelets are a source of inflammatory mediators,³ and the activation of platelets by inflammatory triggers may be a critical component of atherothrombosis.⁴ This review article describes the role of platelets . . . [Full Text of this Article]

Platelets in Primary Hemostasis

Platelet Activation

Clinical Implications

Platelets and Development of Atherosclerotic Lesions

Platelet-Derived Mediators of Inflammation

Reactive Oxygen Species and Platelet Activation

Platelets in Atherogenesis in Humans

Platelets and Arterial Thrombosis

Platelet Activation in Acute Coronary Syndromes

Platelet Activation in Acute Ischemic Stroke

Thromboxane A₂ and Prostacyclin

ADP

Thrombin

Future Directions

Source Information

From the Center of Excellence on Aging, G. d'Annunzio University Foundation, Chieti (G.D.), and the Department of Pharmacology, Catholic University School of Medicine, Rome (C.P.) — both in Italy.

Address reprint requests to Dr. Patrono at Università Cattolica del S. Cuore, Largo F. Vito 1, 00168 Rome, Italy, or at carlo.patrono@rm.unicatt.it.

Related Letters:

Platelet Activation and Atherothrombosis
Kapoor J. R., Patrono C., Davì G.
Extract | Full Text | PDF  
N Engl J Med 2008; 358:1638-1639, Apr 10, 2008. Correspondence

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