Investigations into the interaction between epithelial cancercells and adjacent stroma have revealed paracrine interactionsthat enhance the tumorigenic characteristics of the cancer cell.1Tumor-associated stroma have been reported to have increasedmotility and invasive potential and are thought to secrete distinct,abnormal molecules into the extracellular matrix. Although weonce assumed that all fibroblasts are alike, we now know thatstromal fibroblasts from different tissues have different gene-expressionprofiles, even when cultivated under the same culture conditions.All the data suggest that even fibroblasts of similar appearancehave markedly different characteristics. Still, the primaryassumption is that tumor-associated fibroblasts . . . [Full Text of this Article]
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Dr. Liu is the executive director of the Genome Institute of Singapore at the Agency for Science, Technology, and Research, Singapore.
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