Although protocols differ among transplantation centers, mostimmunosuppressive strategies for kidney-transplant recipientsare built on two core practices: delivery of immunosuppressionin two phases, usually termed induction and maintenance, andthe concurrent use of several immunosuppressive medicationsthat work at various sites in the cell cycle and have nonoverlappingtoxic effects. In general, the induction phase involves theinitial use of the same oral immunosuppressive medications thatare prescribed at lower doses during long-term maintenance.Induction doses are reduced during the first 2 to 4 months aftertransplantation until maintenance levels are achieved. Inductionmay also include the administration of . . . [Full Text of this Article]
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From the Department of Medicine, Division of Nephrology, University of Michigan Medical School, Ann Arbor.
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