Preterm birth is defined as birth before the completion of 37weeks of gestation. The frequency of preterm birth in the UnitedStates increased from 10.7% in 1992 to 12.3% in 2003.1 Pretermbirths can be categorized as those undertaken because of a specificindication or as spontaneous preterm births. Indicated pretermbirths occur when a health care provider delivers a baby becauseof medical or obstetrical complications that jeopardize thehealth of the mother or the fetus. Spontaneous preterm birthsoccur as a consequence of spontaneous preterm labor or pretermrupture of fetal membranes before the onset of labor. . . . [Full Text of this Article]
Mechanisms of Preterm Labor
Pathophysiology of Preterm Birth
Diagnosis of Acute Preterm Labor
Treatment Strategies
β-Adrenergic–Receptor Agonists
Nitric Oxide Donors
Magnesium Sulfate
Calcium-Channel Blockers
Cyclooxygenase Inhibitors
Oxytocin-Receptor Antagonists
Implications of Treatment
Current Clinical Tools and Management
Therapy Decisions
Source Information
From the Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh.
Address reprint requests to Dr. Simhan at 300 Halket St., Pittsburgh, PA 15213, or at hsimhan@mail.magee.edu.
Related Letters:
Prevention of Preterm Delivery
Tsatsaris V., Azria E., Goffinet F., Morrison E. A.B., Cushman L. F., Simhan H. N., Caritis S. N.
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N Engl J Med 2007;
357:1979-1980, Nov 8, 2007.
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