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Clinical Implications of Basic Research
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Volume 357:708-710 August 16, 2007 Number 7
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Bugging of the Intestinal Mucosa
Clara Abraham, M.D., and Judy H. Cho, M.D.

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An enormous array of adaptive mechanisms on both sides of the host–microbial interface reflects a complex coevolution. Deciphering the cross-talk at this interface may yield new insights into its relevance to health and disease. For example, Barnich et al.1 have recently described a host response to bacteria in patients with Crohn's disease.

A vast variety and number of microorganisms normally live within the human intestine.2 The intestinal microbiome coexists with the intestinal immune system and is required for normal intestinal immune development and homeostasis. Several mechanisms prevent luminal bacteria, or specific subgroups thereof, from damaging the body or entering it . . . [Full Text of this Article]


Source Information

From the Department of Medicine, University of Chicago, Chicago (C.A.); and the Department of Medicine and Genetics, Yale University School of Medicine, New Haven, CT (J.C.).



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