FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 357:827-829 August 23, 2007 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Adrogué, H. J. PubMed Citation

To the Editor: In their review of the roles of sodium and potassium in the pathogenesis of hypertension, Adrogué and Madias (May 10 issue)¹ appropriately emphasize the central roles of an excess of sodium, the expansion of extracellular fluid volume, the release of digitalis-like factor, a potassium deficit, and Na⁺/K⁺–ATPase inhibition. Digitalis-like factor is found mainly in the low-renin, volume-expanded types of hypertension. Recent studies suggest that ouabain is not the only Na⁺/K⁺–ATPase inhibitor in hypertension; marinobufagenin, a member of the bufadienolide family, is also often present and participates in the pathogenesis of sodium-induced hypertension.²

Francis . . . [Full Text of this Article]

HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  HELP  |  beta.nejm.org Comments and questions? Please contact us. The New England Journal of Medicine is owned, published, and copyrighted © 2008 Massachusetts Medical Society. All rights reserved.