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Previous Volume 357:927-929 August 30, 2007 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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High-resolution genomewide association studies using panels of 300,000 to 1 million single-nucleotide polymorphisms (SNPs) aim to define genetic risk profiles of common diseases. These studies herald a fundamentally new opportunity to explore human biology and medicine, since they are unbiased by previous hypotheses or assumptions about the nature of genes that influence complex diseases. Underscoring the importance of this approach is the fact that many genetic variants identified as risk factors in type 2 diabetes and Crohn's disease by such studies have been localized to previously unsuspected pathways, to genes without a known function, or to noncoding regions of genes.

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From the University of Helsinki and the National Public Health Institute, Biomedicum, Helsinki, Finland; and the Broad Institute, Massachusetts Institute of Technology, Cambridge, MA.

This article (10.1056/NEJMe078147) was published at www.nejm.org on July 29, 2007.

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N Engl J Med 2007; 357:2199-2201, Nov 22, 2007. Correspondence

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