FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 357:927-929 August 30, 2007 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by The International Multiple Sclerosis Genetics Consortium PubMed Citation

High-resolution genomewide association studies using panels of 300,000 to 1 million single-nucleotide polymorphisms (SNPs) aim to define genetic risk profiles of common diseases. These studies herald a fundamentally new opportunity to explore human biology and medicine, since they are unbiased by previous hypotheses or assumptions about the nature of genes that influence complex diseases. Underscoring the importance of this approach is the fact that many genetic variants identified as risk factors in type 2 diabetes and Crohn's disease by such studies have been localized to previously unsuspected pathways, to genes without a known function, or to noncoding regions of genes.

. . . [Full Text of this Article]

Source Information

From the University of Helsinki and the National Public Health Institute, Biomedicum, Helsinki, Finland; and the Broad Institute, Massachusetts Institute of Technology, Cambridge, MA.

This article (10.1056/NEJMe078147) was published at www.nejm.org on July 29, 2007.

Related Letters:

Genomewide Study of Multiple Sclerosis
Ramagopalan S. V., Anderson C., Sadovnick A. D., Ebers G. C., Matesanz F., Fernández O., Alcina A., Chaudhuri A., Behan P. O., Hafler D. A., Compston A., Hauser S. L., the International Multiple Sclerosis Genetics Consortium
Extract | Full Text | PDF  
N Engl J Med 2007; 357:2199-2201, Nov 22, 2007. Correspondence

This article has been cited by other articles:

• DeLuca, G. C., Ramagopalan, S. V., Herrera, B. M., Dyment, D. A., Lincoln, M. R., Montpetit, A., Pugliatti, M., Barnardo, M. C. N., Risch, N. J., Sadovnick, A. D., Chao, M., Sotgiu, S., Hudson, T. J., Ebers, G. C. (2007). An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus. Proc. Natl. Acad. Sci. USA 104: 20896-20901 [Abstract] [Full Text]  
• Ramagopalan, S. V., Anderson, C., Sadovnick, A. D., Ebers, G. C., Matesanz, F., Fernandez, O., Alcina, A., Chaudhuri, A., Behan, P. O., Hafler, D. A., Compston, A., Hauser, S. L., the International Multiple Sclerosis Genetics Cons, (2007). Genomewide Study of Multiple Sclerosis. NEJM 357: 2199-2201 [Full Text]