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Previous Volume 358:82-83 January 3, 2008 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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A general rule of cell biology is that once a cell commits to a particular differentiation pathway, there is no turning back. It is thought that the event triggering differentiation activates a distinct gene-expression program that is restricted by cell type; this program results in epigenetic changes in the DNA and in modification of accompanying proteins that locks in this state. Understanding cell-lineage commitment is important, because it lies at the heart of attempts to reprogram mature cell types into stem cells and to direct their further differentiation for therapeutically useful outcomes. Cobaleda and colleagues¹ recently contributed to this understanding . . . [Full Text of this Article]

Source Information

From the Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

This article has been cited by other articles:

• Re, R. N., Cook, J. L. (2008). The physiological basis of intracrine stem cell regulation. Am. J. Physiol. Heart Circ. Physiol. 295: H447-H453 [Abstract] [Full Text]