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Previous Volume 358:95 January 3, 2008 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their review of uremia, Meyer and Hostetter (Sept. 27 issue)¹ mention that cellular functions can be disordered in uremia, and as an example, they cite inhibition of sodium–potassium ATPase by retained digitalis-like substances such as marinobufagenin. However, they do not discuss the significance of sodium–potassium pump inhibition. One effect of sodium–potassium pump inhibition in some cells is depolarization of the membrane potential due to unequal transfer of sodium and potassium across cell membranes by the pump, which can affect the function of many types of cells. In vascular smooth muscle, the effect is influx of calcium . . . [Full Text of this Article]

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