It is widely assumed that respiratory-muscle weakness, eitherintrinsic or due to fatigue, leads to respiratory failure.1For the past 30 years, attention has been focused on whetherthe diaphragm muscle is especially susceptible to fatigue inpatients with chronic pulmonary disease and critical illness,increasing the potential for respiratory failure.2,3 In the1980s and early 1990s, this concern led to the practice of restingthe diaphragm with the use of mechanical ventilation to reversefatigue. However, in studies examining transdiaphragmatic pressurein patients being weaned from mechanical ventilation, failureto wean was not consistently associated with a decrease in . . . [Full Text of this Article]
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From the Departments of Physiology and Biomedical Engineering and Anesthesiology, Mayo Clinic, Rochester, MN.
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