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Clinical Implications of Basic Research
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Volume 358:1397-1398 March 27, 2008 Number 13
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Cardiac Connections — The Antiarrhythmic Solution?
Heather S. Duffy, Ph.D.

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At a recent meeting to discuss cell-based therapies for cardiovascular disease, a colleague asked, "With intracardiac devices being so successful, why would anybody want to put unknown cells into sick hearts?" Although horse-and-buggy drivers probably made similar comments about the first automobiles, the question bears consideration. After injury, myocardial regeneration occurs slowly, if at all. The hypothesis behind cell-based therapy for cardiac injury is that adding healthy cells to injured myocardium increases the rate of recovery1 and, in so doing, improves cardiac function and prevents life-threatening arrhythmias. Yet, to date, success with cell therapies has been limited, and under some . . . [Full Text of this Article]


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From the Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York.




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