At a recent meeting to discuss cell-based therapies for cardiovasculardisease, a colleague asked, "With intracardiac devices beingso successful, why would anybody want to put unknown cells intosick hearts?" Although horse-and-buggy drivers probably madesimilar comments about the first automobiles, the question bearsconsideration. After injury, myocardial regeneration occursslowly, if at all. The hypothesis behind cell-based therapyfor cardiac injury is that adding healthy cells to injured myocardiumincreases the rate of recovery1 and, in so doing, improves cardiacfunction and prevents life-threatening arrhythmias. Yet, todate, success with cell therapies has been limited, and undersome . . . [Full Text of this Article]
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From the Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York.
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