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Correspondence
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Volume 358:1634-1636 April 10, 2008 Number 15
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Breast-Cancer Stromal Cells with TP53 Mutations

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by Patocs, A.
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To the Editor: Patocs et al. (Dec. 20, 2007, issue)1 report a frequency of TP53 mutations in fibroblasts associated with sporadic breast carcinoma of 27.4%, and they show that mutation status is associated with regional nodal metastasis. If confirmed, this finding would represent an important discovery.

We sought to confirm their findings by direct sequencing of exons 4 through 9 of TP53 in microdissected areas of stroma (<5 mm from the epithelial cancer interface) from 10 fresh-frozen sporadic breast-cancer specimens and 7 primary breast-carcinoma–associated fibroblast cultures.2,3 No mutation was detected in any of these 17 samples. The reason for this . . . [Full Text of this Article]



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