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Volume 358:1865-1866 April 24, 2008 Number 17
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Cardiac-Resynchronization Therapy

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by Beshai, J. F.
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To the Editor: A QRS duration longer than 120 msec is the only validated selection criterion for cardiac-resynchronization therapy (CRT). However, observational studies have shown a high prevalence of mechanical dyssynchrony in patients with narrow QRS complexes. Beshai et al. (Dec. 13 issue)1 report on the Cardiac Resynchronization Therapy in Patients with Heart Failure and Narrow QRS (RethinQ) study, the first randomized trial examining the performance of CRT in this specific population. Its negative results must be interpreted from the perspective of the study methods used. Patient selection was based on echocardiographic criteria, which, in the Predictors of Response to . . . [Full Text of this Article]



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