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Previous Volume 358:188-190 January 10, 2008 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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As the balance of evidence regarding corticosteroid treatment for septic shock shifts once again toward the negative, the study by Sprung et al.¹ in this issue of the Journal elicits a strong feeling of déjà vu. Will the historical fate of high-dose corticosteroids, which were largely abandoned when the benefit observed in early studies could not be replicated in larger trials,^2,3 now befall "physiologic-dose" corticosteroids?

The rationale for therapy with corticosteroids at a physiologic dose (i.e., 200 to 300 mg of hydrocortisone per day) originated in the observations that patients with septic shock who had a reduced response to corticotropin . . . [Full Text of this Article]

Source Information

From the George Institute for International Health, the University of Sydney, and the Royal North Shore Hospital — all in Sydney.

This article has been cited by other articles:

• Sibila, O., Agusti, C., Torres, A. (2008). Corticosteroids in severe pneumonia. Eur Respir J 32: 259-264 [Abstract] [Full Text]  
• Foex, B. A, Thomson, H. E (2008). Steroids in sepsis, etomidate and Pearl Harbor. Emerg. Med. J. 25: 469-470 [Full Text]  
• (2008). Steroids in Septic Shock: Not Looking Good. JWatch Emergency Med. 2008: 1-1 [Full Text]  
• (2008). Adjunctive Therapy in Septic Shock and Severe Sepsis. JWatch Infect. Diseases 2008: 1-1 [Full Text]