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Correspondence
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Volume 358:195-196 January 10, 2008 Number 2
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Kidney-Transplant Rejection and Anti-MICA Antibodies

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by Zou, Y.
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To the Editor: With respect to the report by Zou et al. (Sept. 27 issue)1 on kidney-transplant rejection and major-histocompatibility-complex (MHC) class I–related chain A (MICA) antibodies, caution is needed in asserting that presensitization against MICA antigens might contribute to allograft loss among recipients who are well matched for HLA. Not stated are possible variations in the methodologies, testing criteria, and cutoff values used for anti-HLA–antibody testing and panel-reactive antibody determination among the 20 centers in 13 countries that participated in the study from 1990 to 2004. Moreover, whereas the detection of anti-MICA antibodies was retrospectively performed by one laboratory . . . [Full Text of this Article]



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