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In 1934, Gregory Pincus mixed rabbit eggs and sperm in the glass top of his watch, implanted the developing embryo in a surrogate mother rabbit, and created offspring through in vitro fertilization. Three years later, an editorial in the Journal, "Conception in a Watch Glass" (N Engl J Med 1937;217:678-9), expressed enthusiasm for the application of this technique in humans: "What a boon for the barren woman with closed tubes!"
Four decades passed, though, before the first human birth from in vitro fertilization. The arrival of Louise Brown on July 25, 1978, ended a scientific quest but started a policy
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