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Correspondence
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Volume 358:2180-2182 May 15, 2008 Number 20
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Selective Publication of Antidepressant Trials

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 by Turner, E. H.
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To the Editor: The importance of the study reported by Turner et al. (Jan. 17 issue),1 on selective publication of antidepressant trials, can hardly be overstated because it shows how researchers and clinicians are deprived of accurate data, resulting in a wrong understanding of antidepressant efficacy. The most serious implication of this study is that guidelines for the treatment of depression may be inaccurate, since they are often based on meta-analyses of published data alone.2,3

This current system makes it impossible for scientific journals to provide a valid picture of the efficacy of antidepressants. Therefore, we propose that meta-analyses be . . . [Full Text of this Article]




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