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Previous Volume 358:2185-2186 May 15, 2008 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Triptans are serotonin-receptor agonists used in the treatment of migraine headaches. When administered in combination with certain drugs, such as selective serotonin-reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs), triptans may precipitate the serotonin syndrome, a potentially life-threatening condition characterized by a triad of clinical manifestations — changes in mental status, autonomic hyperactivity, and neuromuscular abnormalities.^1,2 The cause of the serotonin syndrome is related to altered serotonin synthesis, release, reuptake, metabolism, or receptor agonism.³ We investigated whether triptan monotherapy is associated with the serotonin syndrome by searching for such cases in the Food and Drug Administration's Adverse . . . [Full Text of this Article]

Related Letters:

More on Serotonin Syndrome Associated with Triptan Monotherapy
Evans R. W., Soldin O. P.
Extract | Full Text | PDF  
N Engl J Med 2008; 359:870-871, Aug 21, 2008. Correspondence

This article has been cited by other articles:

• Wenzel, R. G, Tepper, S., Korab, W. E, Freitag, F. (2008). Serotonin Syndrome Risks When Combining SSRI/SNRI Drugs and Triptans: Is the FDA's Alert Warranted?. The Annals of Pharmacotherapy 42: 1692-1696 [Abstract] [Full Text]  
• Evans, R. W., Soldin, O. P. (2008). More on Serotonin Syndrome Associated with Triptan Monotherapy. NEJM 359: 870-871 [Full Text]