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Correspondence
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Volume 358:2293-2295 May 22, 2008 Number 21
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Iron-Overload–Related Disease in HFE Hereditary Hemochromatosis

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by Allen, K. J.
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To the Editor: The report by Allen et al. (Jan. 17 issue)1 on iron-overload–related disease in patients with HFE hereditary hemochromatosis states that among men, the clinical penetrance among HFE C282Y homozygotes was 28.4%. Our study showed that only about 2% of male C282Y homozygotes had full-blown clinical disease.2 We are disappointed that the authors still suggest that our results were biased because we excluded patients with a prior diagnosis of hemochromatosis, even after we showed them that the results were unaltered without this exclusion.3 Moreover, contrary to their assertion, all our patients were examined by a physician.

In reality, . . . [Full Text of this Article]



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