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Previous Volume 358:2511-2512 June 5, 2008 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Despite great expectations, therapeutic angiogenesis with the vascular endothelial growth factor (VEGF) and related molecules for the treatment of ischemic heart and peripheral arterial occlusive disease has thus far failed in the clinic, so alternative strategies to stimulate revascularization of ischemic tissues are required. Arany and colleagues¹ recently reported that the metabolic sensor peroxisome proliferator-activated receptor- coactivator 1 (PGC-1) stimulates angiogenesis in ischemic tissues (Figure 1). With this work, the authors have strengthened the emerging link between angiogenesis and metabolism, two processes that are turning out to be closely intertwined. The study by Arany et al. could . . . [Full Text of this Article]

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From the Vesalius Research Center, VIB-KU Leuven (P.C.) and the Laboratory of Cell Metabolism (M.B.), Katholieke Universiteit Leuven — both in Leuven, Belgium.

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