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Volume 358:2738-2741 June 19, 2008 Number 25
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Five Genetic Variants Associated with Prostate Cancer

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 by Gelmann, E. P.
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 by Zheng, S. L.
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To the Editor: We agree with Zheng et al. (Feb. 28 issue)1 that additional research is needed to assess the value of their finding of genetic variants associated with the risk of prostate cancer. Unfortunately, the planned marketing of a test based on this study2 is premature and may cause more harm than good. Finding a genetic association is only the first step in the continuum of translating research into practice.3 The results have not been independently confirmed, and adding the genetic test results to age, region, and family history only marginally improved risk prediction (the area under the curve . . . [Full Text of this Article]




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