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Volume 358:308-309 January 17, 2008 Number 3
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CTGF Polymorphism Associated with Systemic Sclerosis

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by Fonseca, C.
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To the Editor: In the study reported by Fonseca et al. (Sept. 20 issue),1 the G–945C substitution in the promotor region of the connective-tissue growth factor (CTGF) gene was clearly demonstrated to be associated with susceptibility to systemic sclerosis. We have two questions. First, generally, the majority of patients with diffuse cutaneous systemic sclerosis have cardiac abnormalities, which can often cause death. Are there any data on the association between this single-nucleotide polymorphism (SNP) and the cardiovascular findings? Second, overall, women are affected by systemic sclerosis approximately three times as often as men, and even more often during . . . [Full Text of this Article]



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