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Editorial
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Volume 358:407-411 January 24, 2008 Number 4
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Immunosuppressive Therapy and Tolerance of Organ Allografts
Thomas E. Starzl, M.D., Ph.D.

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-PubMed Citation
In this issue of the Journal, three articles describe several organ-transplant recipients in whom allografts have maintained good function for up to 5 years without immunosuppressive treatment.1,2,3 In two articles concerning combined kidney and hematopoietic stem-cell transplantation, the authors attributed the successful outcome in their patients to the cotransplantation of donor stem cells.1,2

The third report, by Alexander et al., concerns a young girl who received a completely HLA-mismatched liver from a deceased male donor but did not receive a donor stem-cell infusion.3 The cause of the fulminant hepatic failure with which the patient presented was never firmly established. However, . . . [Full Text of this Article]


Source Information

From the Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center Montefiore, Pittsburgh.




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