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Previous Volume 358:425-428 January 24, 2008 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Stefansson et al. (Aug. 16 issue)¹ report the results of a genomewide association study of the restless legs syndrome (RLS) in an Icelandic series. The analysis revealed that one single-nucleotide polymorphism (SNP) in the BTB (POZ) domain–containing 9 (BTBD9) gene was associated with RLS. Replication in smaller samples from Iceland and the United States showed that the discovery originated from a subgroup of patients with RLS who presented with periodic limb movements in sleep, a common feature of RLS. Winkelmann et al.² performed a similar analysis for patients with RLS who were of European descent, . . . [Full Text of this Article]

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