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Correspondence
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Volume 358:531-532 January 31, 2008 Number 5
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Hepatitis A Vaccine versus Immune Globulin for Postexposure Prophylaxis

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by Victor, J. C.
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To the Editor: Victor et al. (Oct. 25 issue)1 report on their study of hepatitis A vaccine as compared with immune globulin for postexposure prophylaxis. I applaud the recommendation for the postexposure use of hepatitis A vaccine to provide long-term protection. However, I am concerned that the statistical criteria used for determining substantial inferiority detract from the study findings, which indicate a 30% higher rate of hepatitis A after exposure in the group receiving vaccine. The findings support the biologically plausible position that the administration of immediately available antibodies through immune globulin has a time-dependent advantage over the delayed development . . . [Full Text of this Article]



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