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Volume 358:641-644 February 7, 2008 Number 6
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Human Papillomavirus DNA versus Papanicolaou Screening Tests for Cervical Cancer

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by Runowicz, C. D.
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by Mayrand, M.-H.
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To the Editor: The outcome measures appear to have been chosen post hoc by Mayrand et al. (Oct. 18 issue)1 in their screening trial comparing human papillomavirus (HPV) testing with Papanicolaou (Pap) testing.1,2 The "conservative" outcome definition excludes biopsy-confirmed lesions identified at colposcopy but not verified on final excision or on biopsy immediately before ablation. Such lesions are included in the "liberal" definition, along with lesions identified by random biopsy and endocervical curettage. With the conservative definition, HPV testing is clearly superior, whereas with the liberal definition, neither strategy is clearly superior. Lesions included in the liberal definition may have . . . [Full Text of this Article]



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