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Volume 358:746 February 14, 2008 Number 7
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Leukotrienes

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by Peters-Golden, M.
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To the Editor: Peters-Golden and Henderson (Nov. 1 issue)1 review the role of the 5-lipoxygenase pathway of arachidonate metabolism and of leukotrienes, a product of that pathway, in asthma, cardiovascular disease, and cancer. The authors conclude that leukotrienes "probably play a role in other diseases," and we would like to add that they do so in end-stage renal disease. Peripheral-blood mononuclear-cell 5-lipoxygenase activity is involved in low-density lipoprotein oxidation during the early phases of atherogenesis.2,3 We4 and others5 have demonstrated that 5-lipoxygenase activity and expression are up-regulated in peripheral-blood mononuclear cells from patients with uremia who are undergoing maintenance hemodialysis. . . . [Full Text of this Article]



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