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Previous Volume 358:961-963 February 28, 2008 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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As men age, prostate epithelial cells are subjected to substantial stresses, and these stresses can damage DNA, thereby causing cellular transformation. The aging prostate gland acquires numerous foci of cancer cells that arise from distinct clonal transformation events.¹ That most of these foci never develop into clinically detectable cancer is consistent with the frequent finding of prostate cancer during autopsies of asymptomatic men in whom the condition was never diagnosed.²

Susceptibility to prostate cancer has a clear heritable component: men are at an increased risk for the disease if they have a first-degree relative with prostate cancer. The more relatives . . . [Full Text of this Article]

Source Information

From the Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York.

This article (10.1056/NEJMe0708703) was published at www.nejm.org on January 16, 2008.

Related Letters:

Five Genetic Variants Associated with Prostate Cancer
Coates R. J., Khoury M. J., Gwinn M., Gartner C. E., Barendregt J. J., Hall W. D., Janssens A. C. J.W., van Duijn C. M., Severi G., Byrnes G. B., Hopper J. L., Thorat M. A., Vickers A., Lilja H., Scardino P., Eisinger F., Xu J., Isaacs W. B., Grönberg H.
Extract | Full Text | PDF  
N Engl J Med 2008; 358:2738-2741, Jun 19, 2008. Correspondence

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• Coates, R. J., Khoury, M. J., Gwinn, M., Gartner, C. E., Barendregt, J. J., Hall, W. D., Janssens, A. C. J.W., van Duijn, C. M., Severi, G., Byrnes, G. B., Hopper, J. L., Thorat, M. A., Vickers, A., Lilja, H., Scardino, P., Eisinger, F., Xu, J., Isaacs, W. B., Gronberg, H. (2008). Five Genetic Variants Associated with Prostate Cancer. NEJM 358: 2738-2741 [Full Text]