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Clinical Implications of Basic Research
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Volume 359:85-87 July 3, 2008 Number 1
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Removing the Golden Coat of Staphylococcus aureus
Robert S. Daum, M.D.

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Infections caused by Staphylococcus aureus, particularly those that are resistant to methicillin and all available β-lactam antibiotics — the so-called methicillin-resistant S. aureus (MRSA) infections — have been declared a public health imperative. A recent report from the Centers for Disease Control and Prevention1 estimated that 18,650 persons in the United States died from invasive MRSA infections in 2005. A new therapeutic approach to the management of these infections would therefore be welcome.

The development of new antibiotics to treat MRSA infections has slowed for complex reasons.2 Some researchers have pointed to a lack of "new" microbial targets. Indeed, most . . . [Full Text of this Article]


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From the Department of Pediatrics, Section of Infectious Diseases, University of Chicago, Chicago.




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