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Correspondence
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Volume 359:1738-1739 October 16, 2008 Number 16
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Problems Associated with the Use of Thyrogen in Patients with a Thyroid Gland

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To the Editor: Juweid et al. (September 18 issue)1 describe the administration of thyrotropin alfa (Thyrogen) to a patient with thyroid cancer who still has a thyroid gland. Genzyme, the manufacturer of Thyrogen, wants to point out that all regulatory bodies, including the Food and Drug Administration, restrict the use of 0.9-mg intramuscular injections of the drug on two consecutive days to patients who have already had a total or near-total thyroidectomy. This is because of substantial transient thyroid swelling and severe hyperthyroidism that could result in some patients with a thyroid gland who receive a large dose of Thyrogen. . . . [Full Text of this Article]


Related Letters:

Diagnosis of Poorly Differentiated Thyroid Cancer with Radioiodine Scanning after Thyrotropin Alfa Stimulation
Juweid M., O'Dorisio T., Milhem M.
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N Engl J Med 2008; 359:1295-1297, Sep 18, 2008. Correspondence



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