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Volume 359:1850 October 23, 2008 Number 17
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Malignant Gliomas in Adults

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 by Wen, P. Y.
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To the Editor: In their Medical Progress article, Wen and Kesari (July 31 issue)1 review the molecular pathogenesis of gliomas yet do not mention the role that DNA tumor viruses may play in tumor formation. In the same issue, Prins et al.2 provide evidence that strongly supports prior research findings that link cytomegalovirus to glioma. Other DNA viruses, such as JC virus, have been implicated in glioma pathogenesis.3 In this regard, it is also important to note that detection of atypical nuclei and high-proliferation indexes in a brain biopsy led to, in at least one instance, the misdiagnosis of a . . . [Full Text of this Article]




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